NOVELTY – Mucoadhesive granule comprising (i) at least one active compound incorporated in chitosan micro- and/or nanoparticles, and (ii) a granulation excipient, is new. USE – The granules are useful for delivery. ADVANTAGE – The present invention provides granules incorporating active compounds in chitosan nano- and/or microparticles, which have mucoadhesion properties and sustained release of the incorporated active compound. These properties provide a higher in vivo action efficiency of vehiculated drugs or active compounds when administered through mucosae, reduction of side effects, conservation of the activity of labile active compounds, and reduction of the concentration and frequency of dosages. The production process can be operated in a semicontinuous or discontinuous regimen, under sterile conditions, and can be scaled for application in the industrial sector. These granules represent a functional device which is economically feasible and more effective for the administration of drugs and nutraceuticals. DETAILED DESCRIPTION – An INDEPENDENT CLAIM is a process for obtaining the mucoadhesive granule.

Main Application Field

A96 (Medical, dental, veterinary, cosmetic.); A11 (Polysaccharides; natural rubber; other natural polymers (only a restricted range of (modified) natural polymers are included. Thus starch would be excluded, but chemically modified starch included).); B07 (General – tablets, dispensers, catheters (excluding drainage and angioplasty), encapsulation etc, but not systems for administration of blood or saline or IV feeding etc.); D22 (Sterilising, bandages, dressing and skin protection agents – including sterilising agents (other than for food), sutures, plaster casts, bioactive prostheses, contact lenses, diapers, animal litter, timber, preservatives, disinfectants, bactericidal detergents, deodorants, insect repellent compounds, moth proofers, sheep dip (A61L).)

INVENTORS:

ANDRADE SANTANA MARIA HELENA
FERREIRA DA SILVA CLASSIUS
MARTINS FERNANDA

212_GRA;NULOS

Patent number: WO2008131506-A1;BR200705072-A2

PATENT STATUS:

For information contact Inova Unicamp

FOR ADDITIONAL INFORMATION:

parcerias@inova.unicamp.br

+55 (19) 3521-5207 / 2607

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