NOVELTY – 4-Arylaminoquinazoline compounds (I)-(IV) are new. USE – 4-Arylaminoquinazoline compounds used for preparing drug composition for treating cancer (all claimed). ADVANTAGE – The arylaminoquinazoline compounds ensure improved bioavailability and good anti-cancer activity. DETAILED DESCRIPTION – 4-Arylaminoquinazoline compounds of formulae (I)-(IV) are new. R1=-OH, -OCOCH3, OCOCH2CH3, -CONH2, -CON(CH3)2, -CONHCH3, COPh-, -COH, -COCHCH2 or -NH2; R2=Me, -NH2, or N(CH3)2; R1a=-OH, NH2, Me or H; R1b=-OH, -OCOCH3, OCOCH2CH3, -CONH2, -CON(CH3)2, -CONHCH3, COPh-, NHMe or -NH2; R1c=H, Me, NH2 or OH, and R2a=NH2, NHMe, N(Me)2, N(Me)3 or NO2. INDEPENDENT CLAIMS are included for: (1) a method for preparing 2-nitro-4,5-methylenedioxybenzoic acid; (2) a method for preparing 2-amino-4,5-methylenedioxybenzoic acid; (3) a method for preparing 6,7-methylenedioxy-3H-quinazolin-4-one; (4) a method for preparing 4-chloro-6,7-methylenedioxyquinazoline; (5) a method for preparing -N-(phenylamino)-6,7-methylenedioxyquinazoline; (6) a method for preparing 4-N-(4′-chlorophenylamino)-6,7-methylenedioxyquinazoline; (7) a method for preparing 4-N-(4′-bromo-phenylamino)-6,7-methylenedioxyquinazoline; (8) a method for preparing 4-N-(4′-fluoro-phenylamino)-6,7-methylenedioxyquinazoline; (9) a method for preparing 4-N-(4′-iodo-phenylamino)-6,7-methylenedioxyquinazoline; (10) a method for preparing 4-N-(4′-methoxy-phenylamino)-6,7-methylenedioxyquinazoline; and (11) a method for preparing 4-N-(4′-nitro-phenylamino)-6,7-methylenedioxyquinazoline. .

Main Application Field

B02 (Fused ring heterocyclics.)

INVENTORS:

RITTNER ROBERTO
BOCCA CLEVERSON CASSERO
HIEHR NELCI FENALTI
DE OLIVEIRA ANDRE NAZARIO
PINHEIRO DA SILVA THIAGO
DE CARVALHO JOAO ERNESTO

386_INIBIDORES

Patent number: BR201003128-A2

PATENT STATUS:

For information contact Inova Unicamp

FOR ADDITIONAL INFORMATION:

parcerias@inova.unicamp.br

+55 (19) 3521-5207 / 2607

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